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Series GSE44445 Query DataSets for GSE44445
Status Public on Feb 21, 2013
Title IM007 - Mouse infection with A/Vietnam/1203-CIP048_RG4/2004 (H5N1)
Organism Mus musculus
Experiment type Expression profiling by array
Summary A/Vietnam/1203-CIP048_RG4/2004 (H5N1) is an NS1trunc124 mutation in the wild type A/Vietman/1203/2004 (H5N1). The goal of this study was to determine the host response (C57BL/6 mouse model) to the NS1 truncation at both 10^3 PFU and 10^4 PFU.
Overall design Groups of 20-week-old C57BL/6 mice were infected with the A/Vietnam/1203-CIP048_RG4/2004 (H5N1). This is an NS1trunc124 mutation in the wild type A/Vietnam/1203/2004 (H5N1) virus. Infections were done at 10^3 PFU or 10^4 PFU or time-matched mock infected. Time points were 1, 2, 4 and 7 d.p.i. There were 3-5 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.
Contributor(s) Kawoaka Y, Katze M, Eisfeld A, Chang J, Law L, Li C
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Submission date Feb 20, 2013
Last update date Jan 12, 2017
Contact name Michael Katze
Organization name University of Washington
Department Microbiology
Lab Michael G. Katze, Ph.D
Street address Rosen Building 960 Republican St.
City Seattle
State/province WA
ZIP/Postal code 98109-4325
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (52)
GSM1085539 IM007_mock_7d_2
GSM1085540 IM007_10^4_1d_3
GSM1085541 IM007_10^4_4d_4
BioProject PRJNA189980

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44445_RAW.tar 456.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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