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| Status |
Public on May 09, 2016 |
| Title |
Genomic landscape of somatic alterations in esophageal squamous cell carcinoma and gastric cancer |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
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| Summary |
Gastric cancer and esophageal cancer are the 2nd and 6th leading causes of cancer death worldwide. We analyzed DNA copy numbers for 73 ESCC (43 SNP5.0 and 30 500K SNP) with the Affymetrix SNP arrays . Our analyses implicated potential driver mutations involving the following genes: mutations in TP53, BRCA2, NOTCH2, CTNNB1, and LEPREL2; amplification of CCND1, FGF3/4/19, and MYC; and deletion of CDKN2A/B.
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| Overall design |
Copy number analysis of Affymetrix SNP5.0 arrays
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| Contributor(s) |
Hu N, Kadota M, Liu H, Wu H, Su H, Abnet CC, Freedman ND, Yang HH, Wang C, Yan C, Wang L, Gere S, Hutchinson A, Jacobs KB, Song G, Wang QH, Ding T, Qiao YL, Koshiol J, Dawsey SM, Giffen C, Goldstein AM, Taylor PR, Lee M |
| Citation(s) |
26857264 |
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| Submission date |
Jan 14, 2013 |
| Last update date |
May 09, 2016 |
| Contact name |
Maxwell Lee |
| E-mail(s) |
leemax@mail.nih.gov
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| Phone |
240-276-5239
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| Organization name |
National Cancer Institute, NIH
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| Department |
CCR
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| Lab |
Laboratory of Human Carcinogenesis
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| Street address |
Building 37, Room 5120
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL6804 |
[GenomeWideSNP_5] Affymetrix Genome-Wide Human SNP 5.0 Array |
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| Samples (90)
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| Relations |
| BioProject |
PRJNA186512 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE43470_RAW.tar |
2.4 Gb |
(http)(custom) |
TAR (of CEL, TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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