|
| Status |
Public on Aug 31, 2006 |
| Title |
Gefitinib sensitivity in NSCLC cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity.
A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions
All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As.
Keywords: cell response comparison
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| |
|
| Overall design |
Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines
|
| |
|
| Contributor(s) |
Coldren CD, Helfrich BA, Witta SE, Sugita M, Lapadat R, Zeng C, Barón A, Franklin WA, Hirsch FR, Minna JD, Geraci MW, Bunn PA Jr |
| Citation(s) |
16877703, 19634903 |
| |
| Submission date |
Mar 06, 2006 |
| Last update date |
Aug 20, 2019 |
| Contact name |
Christopher D Coldren |
| E-mail(s) |
Chris.Coldren@ucdenver.edu
|
| Phone |
303 724 6056
|
| Organization name |
University of Colorado School of Medicine
|
| Department |
Medicine
|
| Lab |
Pulmonary Sciences and Critical Care Medicine
|
| Street address |
12700 East 17th Place
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL97 |
[HG-U133B] Affymetrix Human Genome U133B Array |
|
| Samples (63)
|
|
| Relations |
| BioProject |
PRJNA94835 |
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