GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE43294 Query DataSets for GSE43294
Status Public on Jan 24, 2013
Title Identification of in vivo, conserved, TAF15 RNA binding sites and the impact of TAF15 on the neuronal transcriptome
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary TAF15, an RNA binding protein was recently implicated in Amyotrophic Lateral Sclerosis (ALS). ALS is a fatal neurodegenerative disease. We report the identification of the conserved neuronal RNA targets of TAF15 and the assessment of the impact of TAF15 depletion on the neuronal transcriptome. Our study uncovers regulation of splicing of sets of neuronal RNAs encoding proteins with essential roles in synaptic activities including glutamergic receptors such as zeta-1 subunit of the glutamate N-methyl-D-aspartate (NMDA) receptor (Grin1).
Overall design Identification of TAF15 neuronal targets using normal human brain samples and mouse neurons. Mouse background: E14Tg2a.4 wildtype cells derived from 129P2/OlaHsd.
Contributor(s) Ibrahim F, Maragkakis M, Alexiou P, Maronski MA, Dichter MA, Mourelatos Z
Citation(s) 23416048
Submission date Jan 04, 2013
Last update date May 15, 2019
Contact name Manolis Maragkakis
Organization name National Institute on Aging
Street address 251 Bayview Blvd
City Baltimore
State/province MD
ZIP/Postal code 21224
Country USA
Platforms (2)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (13)
GSM1060205 TAF15_1_L
GSM1060206 TAF15_2_H
GSM1060207 TAF15_2_L
BioProject PRJNA185286
SRA SRP017777

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43294_RAW.tar 106.2 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap