|
| Status |
Public on Apr 03, 2013 |
| Title |
Expression data from MLL-AF6 positive leukemia cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation system.
|
| |
|
| Overall design |
Leukemic bone marrow cells from a sacrificed moribund mouse were thawed and RNA was extracted using TRIZOL (Invitrogen) and purified further using the RNAeasy kit (Qiagen) under standard conditions and and hybridized onto Affymetrix arrays.
|
| |
|
| Contributor(s) |
Sinha A, Deshpande A, Armstrong S |
| Citation(s) |
23361907 |
| |
| Submission date |
Dec 20, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Amit Sinha |
| E-mail(s) |
amit.sinha@childrens.harvard.edu
|
| Phone |
617-582-7579
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Pediatric Oncology
|
| Lab |
Armstrong Lab
|
| Street address |
44 Binney St
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02135 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (3) |
| GSM1055796 |
MLL-AF6 leukemia Z233 BM Replicate 1 of 3 |
| GSM1055797 |
MLL-AF6 leukemia Z236 BM Replicate 2 of 3 |
| GSM1055798 |
MLL-AF6 leukemia Z237 BM Replicate 3 of 3 |
|
| This SubSeries is part of SuperSeries: |
|
| Relations |
| BioProject |
PRJNA184354 |
