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| Status |
Public on Nov 28, 2012 |
| Title |
Expression data from leptin administration to Lepob/Lepob mice and Lepmkyo/Lepmkyo rats |
| Organisms |
Mus musculus; Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Leptin-responsive genes in the pathway of a leptin signal from the hypothalamus to the liver has not been detected.
We used microarray to detailed the expression of gene in liver in the status of leptin deficiency, and leptin administration. As leptin deficient status, we use Lepmkyo/Lepmkyo rats or Lepob/Lepob mice and their wild type littermates.
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| Overall design |
Recombinant murine leptin (1 microg/mg) and saline was intraperitonealy administrated in 20 weeks old Lepob/Lepob mice and their control littermates, and 20 weeks old Lepmkyo/Lepmkyo rats and their control littermates. In order to detect the early response genes whose expression level were changed before the food intake and body weight would change, we took liver samples 6 hours after administration.
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| Contributor(s) |
Aizawa-Abe M, Ebihara K, Mashimo T, Serikawa T, Nakao K |
| Citation(s) |
23800849 |
| |
| Submission date |
Nov 27, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
MEGUMI AIZAWA-ABE |
| E-mail(s) |
meabe@kuhp.kyoto-u.ac.jp
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| Phone |
+81-75-752-4763
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| Fax |
+81-75-771-9452
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| Organization name |
Kyoto University Hospital
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| Department |
Translational Research Center
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| Street address |
Shokogin Kawahara-cho
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| City |
Kyoto |
| ZIP/Postal code |
606-8507 |
| Country |
Japan |
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| Platforms (2) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA182215 |
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