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Series GSE42335 Query DataSets for GSE42335
Status Public on Jun 18, 2013
Title Expression data for MALT1-responsive genes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In lymphocyte lineages, mucosa-associated lymphoid tissue 1 (MALT1) mediates the nuclear factor-κB activation signal that stimulates progression of malignant tumors. However, its expression is inactivated in oral carcinoma patients with worse prognosis. Unveiling genes under the control of MALT1 will provide valuable information for understanding of the mechanism of carcinoma progression.
We profiled gene datasets altered in response to MALT1 in oral carcinoma cells by the microarray analysis. Totally, 2,933 genes with a fold change ≥ ±2.0 and P < 0.05 were identified.
Overall design HSC2 oral carcinoma cells were used for RNA extraction and hybridization on Affimetrix microarrays. We sought to obtain homogenous populations of MALT1-resonsive genes in order to increase the resolution of expression profiles. To this end, we used HSC2 cells stably expressing MALT1 (n=3) and vector alone (n=3) for the analysis.
Contributor(s) Chiba T, Imai K
Citation(s) 23778523
Submission date Nov 16, 2012
Last update date Dec 06, 2018
Contact name Kazushi Imai
Phone 81-3-3261-8857
Fax 81-3-3261-8875
Organization name Nippon Dental Universty
Department Biochemistry
Street address 1-9-20 Fujimi, Chiyoda-ku
City Tokyo
ZIP/Postal code 102-8159
Country Japan
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (6)
GSM1038066 MALT1-HSC2, rep1
GSM1038067 MALT1-HSC2, rep2
GSM1038068 MALT1-HSC2, rep3
BioProject PRJNA181102

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42335_RAW.tar 12.9 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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