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| Status |
Public on Jan 29, 2013 |
| Title |
Comparative transcriptome analysis of Th22 and Th17 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Microarray was used to delineate the global gene expression profile underlying the specific developmental program of two divergent antigen-specific T helper subsets (Th22 versus Th17) by identifying upregulation or downregulation of key lineage-determining transcription factors, cytokines, chemokines and other genes that govern their functional attributes.
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| Overall design |
To identify factors that might distinguish the Th22 and Th17 developmental programs, comparative global transcriptome analysis between these 2 subsets was performed. Naïve splenic CD4+ T cells from OT-II-transgenic mice were isolated and grown in vitro under T-helper lineage-specific conditions in the presence of cognate antigen (ovalbumin) to identify their distinctive global gene-regulation profiles.
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| Contributor(s) |
Basu R, Weaver CT, Crossman DK |
| Citation(s) |
23200827 |
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| Submission date |
Nov 15, 2012 |
| Last update date |
Mar 04, 2019 |
| Contact name |
CASEY T WEAVER |
| Organization name |
University of Alabama at Birmingham
|
| Department |
Pathology
|
| Street address |
845 19th Street South
|
| City |
Birmingham |
| State/province |
Alabama |
| ZIP/Postal code |
35294-2170 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA181089 |
