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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 16, 2012 |
| Title |
IKKe coordinates invasion and metastasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
IKKe was identified previously as a breast cancer oncogene and was associated with poor clinical outcome in ovarian cancer.
In order to elucidate functional roles of IKKe, we used microarray analysis to identify genes changed upon IKKe shRNA knockdown and compared with genes affected in ovarian cancers
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| Overall design |
IKKe was knockdowned by 2 different IKKe shRNAs in Ovcar5 in 6 replicates and candidate downstream targets were selected if changed by both shRNAs
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| Contributor(s) |
Kim M, Hsu S, Hernandez L, Grajales V, Noonan A, Anver M, Davidson B, Annunziata CM |
| Citation(s) |
22942254 |
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| Submission date |
Nov 15, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Marianne Kwang-Hee Kim |
| E-mail(s) |
marianne.kim@nih.gov
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| Organization name |
NIH/NCI
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| Department |
Women's Malignancies Branch
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| Street address |
10 Center Dr. 4B55
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (18)
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| GSM1037642 |
IKKe B2 shRNA, biological rep4 |
| GSM1037643 |
IKKe B2 shRNA, biological rep5 |
| GSM1037644 |
IKKe B2 shRNA, biological rep6 |
| GSM1037645 |
IKKe B6 shRNA, biological rep1 |
| GSM1037646 |
IKKe B6 shRNA, biological rep2 |
| GSM1037647 |
IKKe B6 shRNA, biological rep3 |
| GSM1037648 |
IKKe B6 shRNA, biological rep4 |
| GSM1037649 |
IKKe B6 shRNA, biological rep5 |
| GSM1037650 |
IKKe B6 shRNA, biological rep6 |
| GSM1037651 |
SC4 neg shRNA, biological rep1 |
| GSM1037652 |
SC4 neg shRNA, biological rep2 |
| GSM1037653 |
SC4 neg shRNA, biological rep3 |
| GSM1037654 |
SC4 neg shRNA, biological rep4 |
| GSM1037655 |
SC4 neg shRNA, biological rep5 |
| GSM1037656 |
SC4 neg shRNA, biological rep6 |
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| Relations |
| BioProject |
PRJNA181022 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE42320_RAW.tar |
82.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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