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| Status |
Public on Oct 20, 2012 |
| Title |
Expression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechanistic basis underlying these effects are not fully understood. We have used adult GRK2 hemizygous mice (GRK2+/-) as a model to assess the effects of a sustained systemic inhibition of GRK2 in heart tissue with age.
We used microarrays to determine the global programme of gene expression underlying cardioprotection in GRK2 hemizygous mice.
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| Overall design |
9 month-old mice hearts were collected for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Lucas E, Jurado-Pueyo M |
| Citation(s) |
25239306 |
| |
| Submission date |
Oct 19, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Lucas Elisa |
| E-mail(s) |
elucas@cbm.uam.es
|
| Organization name |
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)
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| Department |
Molecular Biology
|
| Street address |
Nicolas Cabrera 1
|
| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28049 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE41810 |
GRK2 deficiency confers cardioprotective profile. |
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| Relations |
| BioProject |
PRJNA178001 |
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