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Series GSE41658 Query DataSets for GSE41658
Status Public on Nov 01, 2013
Title Methylomic analysis identifies the involvement of migration and adhesion genes in the ageing of primary haematopoietic stem cells
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary we utilize Nano-MeDIP-seq for the analysis of the LT-HSC methylome and, for the first time, simultaneously interrogate the methylome and transcriptome of a homogeneous population of primary murine HSCs, in order to define the underlying causes of changes in HSC functionality during normal ageing.
Overall design We isolated and phenotyped primary LT-HSCs from young, middle-aged and old mice and subjected them to comprehensive methylome (MeDIP-seq) and transcriptome (RNA-seq) analysis.
Contributor(s) Taiwo O, Wilson GA, Emmett W, Morris T, Bonnet D, Adejumo T, Pearce D, Beck S
Citation(s) 23949429
Submission date Oct 17, 2012
Last update date May 15, 2019
Contact name Gareth Wilson
Organization name UCL Cancer Institute
Street address 23 Huntley Street
City London
ZIP/Postal code WC1E 6BT
Country United Kingdom
Platforms (2)
GPL9250 Illumina Genome Analyzer II (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (18)
GSM1021215 Young_1_MeDIP
GSM1021216 Young_2_MeDIP
GSM1021217 Young_3_MeDIP
BioProject PRJNA177844
SRA SRP016510

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41658_RAW.tar 538.2 Mb (http)(custom) TAR (of BW, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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