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| Status |
Public on Oct 17, 2012 |
| Title |
Genome-wide Tinman binding sites in early and late Drosophila embryos |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
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| Summary |
The Drosophila transcription factor Tinman (Tin) is involved in embryonic heart development. We have analyzed genomic binding sites for Tin using a ChIP-chip strategy, making use of our high-quality antibody and Affymetrix Drosophila Tiling Arrays. We sampled to time points (early: 3-5.5h AEL and late: 5-8h AEL) that see distinct Tin expression in the embryo. Our data analysis yielded 2548 binding events in early and 988 binding events in late embryos.
Our results are described in Jin et al. "Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures"; submitted to PLoS Genetics
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| Overall design |
Drosophila whole embryos, ChIPed with anti-Tin antibody or IgG control, hybridised to Affymetrix Drosophila tiling arrays, data analysed using MAT
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| Contributor(s) |
Jin H, Stojnic R, Adryan B, Ozdemir A, Stathopoulos A, Frasch M |
| Citation(s) |
23326246 |
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| Submission date |
Oct 16, 2012 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Boris Adryan |
| E-mail(s) |
ba255@cam.ac.uk
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| Phone |
+44-1223-760209
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| URL |
http://logic.sysbiol.cam.ac.uk
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| Organization name |
University of Cambridge
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| Department |
Cambridge Systems Biology Centre
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| Street address |
Tennis Court Road
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| City |
Cambridge |
| ZIP/Postal code |
CB2 1QR |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL5919 |
[Dm35b_MR] Affymetrix Drosophila Tiling 1.0R Array |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA177771 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE41628_RAW.tar |
315.4 Mb |
(http)(custom) |
TAR (of BAR, BED, CEL, SGR) |
| Processed data provided as supplementary file |
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