 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 10, 2012 |
| Title |
Pancreatic gene expression associated with cerulein induced chronic pancreatitis in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A frequently used experimental model of chronic pancreatitis (PC) recapitulating human disease is repeated injection of cerulein to mice. We found that two common substrains of C57BL/6 , C56BL/6J (Jackson) and C57BL/6NHsd (Harlan), exhibit different degree of CP with C57BL/6J beeing more susceptible to repetitive cerulein induced CP. The goal of this study was to identify genes associated with CP and also to identify genes differentially regulated between two substrains as candidates for the CP progression.
|
| |
|
| Overall design |
RNAs were isolated from the pancreas of 8-week old Jackson and Harlan mice after the cerulein induction of chronic pancreatitis and hybridized on Affymetrix microarrays. Saline injected mice were used as controls. Three mice from each experimental and control groups were used in the experiment.
|
| |
|
| Citation(s) |
23845568 |
| |
| Submission date |
Oct 09, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Audrey Watson |
| E-mail(s) |
awatso21@slu.edu
|
| Organization name |
Saint Louis University
|
| Street address |
1100 South Grand
|
| City |
Saint Louis |
| State/province |
Missouri |
| ZIP/Postal code |
63104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (12)
|
| GSM1016804 |
Harlan mice, cerulein treated, biological rep1 |
| GSM1016805 |
Harlan mice, cerulein treated, biological rep 2 |
| GSM1016806 |
Harlan mice, cerulein treated, biological rep 3 |
| GSM1016807 |
Jackson mice, cerulein treated, biological rep1 |
| GSM1016808 |
Jackson mice, cerulein treated, biological rep 2 |
| GSM1016809 |
Jackson mice, cerulein treated, biological rep 3 |
| GSM1016810 |
Harlan mice, control, biological rep1 |
| GSM1016811 |
Harlan mice, control, biological rep 2 |
| GSM1016812 |
Harlan mice, control, biological rep 3 |
| GSM1016813 |
Jackson mice, controls, biological rep1 |
| GSM1016814 |
Jackson mice, control, biological rep 2 |
| GSM1016815 |
Jackson mice, control, biological rep 3 |
|
| Relations |
| BioProject |
PRJNA176923 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE41418_RAW.tar |
34.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...