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Series GSE4125 Query DataSets for GSE4125
Status Public on Feb 01, 2006
Title Renal Cell Carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe gene expression profiles in 41 renal tumors determined by using DNA microarrays containing 22,648 unique cDNAs representing 17,083 different UniGene Clusters, including 7230 characterized human genes. Differences in the patterns of gene expression among the different tumor types were readily apparent; hierarchical cluster analysis of the tumor samples segregated histologically distinct tumor types solely based on their gene expression patterns. Conventional renal cell carcinomas with clear cells showed a highly distinctive pattern of gene expression. Papillary carcinomas formed a tightly clustered group, as did tumors arising from the distal nephron and the normal kidney samples. Surprisingly, conventional renal cell carcinomas with granular cytoplasm were heterogeneous, and did not resemble any of the conventional carcinomas with clear cytoplasm in their pattern of gene expression. Characterization of renal cell carcinomas based on gene expression patterns provides a revised classification of these tumors and has the potential to supply significant biological and clinical insights.
A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied.
Keywords: disease_state_design
 
Overall design Computed
Web link http://genome-www.stanford.edu/renal_cell_carcinoma/
 
Contributor(s) Shinghal R
Citation(s) 12598325
Submission date Jan 30, 2006
Last update date Mar 16, 2012
Organization Stanford Microarray Database (SMD)
E-mail(s) array@genome.stanford.edu
Phone 650-498-6012
URL http://genome-www5.stanford.edu/
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (4)
GPL2649 SHT
GPL2671 SHAJ
GPL2831 SHR
Samples (44)
GSM94476 CKR001 Conventional/clear RCC II Caval Thrombus
GSM94477 SKN005 Normal Kidney
GSM94478 SKR012 Conventional/clear RCCA III Thrombus
Relations
BioProject PRJNA94925

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Supplementary data files not provided
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