|
| Status |
Public on Jan 01, 2014 |
| Title |
Deciphering the genetics of mammalian limb growth |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have used DGE-SAGE, a digital transcriptomics tool, to determine the expression profile of E14.5 mouse forelimbs and hindlimbs. The forelimb, hindlimb developmental lag combined with the analysis of these datasets allow us a better insight into the dynamics of the limb growth genetic network, in particular the characterisation of genes that are differentially expressed and are putative modulators of limb growth and or candidates for limb malformation syndromes.
Conclusions: The datasets and results presented in this study allow us to extend the current knowledge of the limb development and constitute an extremely relevant resource for research into the genetics of organ growth and thus ontogenesis.
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| |
|
| Overall design |
DGE-SAGE expression profiles for E14.5 mouse forelimb and hindlimb
|
| |
|
| Contributor(s) |
Coutinho P, Baldock R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 28, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Pedro Coutinho |
| E-mail(s) |
pedro.coutinho@igmm.ed.ac.uk
|
| Phone |
00441313322471
|
| Fax |
00441314678456
|
| Organization name |
University of Edinburgh
|
| Department |
MRC IGMM
|
| Lab |
Biomedical systems Analysis section
|
| Street address |
western general hospital, crewe rd
|
| City |
Edinburgh |
| ZIP/Postal code |
EH4 2XU |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL9250 |
Illumina Genome Analyzer II (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA176222 |
| SRA |
SRP015930 |
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