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Series GSE4097 Query DataSets for GSE4097
Status Public on May 01, 2006
Title Analysis of target genes induced by the Amyloid Precursor Protein Intracellular Domain
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer’s disease (AD). Processing of APP by β- and γ-secretase activities results in the production of ß-amyloid (Aß), the main constituent of Alzheimer plaques, but also in the generation of the APP intracellular domain (AICD). Recently, it has been demonstrated that AICD has transactivation potential, however, the targets of AICD dependent gene regulation and hence the physiological role of AICD remain largely unknown. In this work we analysed transcriptome changes during AICD dependent gene regulation using a human neural cell culture system inducible for expression of AICD, its co-activator Fe65, or the combination of both. Induction of AICD was associated with increased expression of genes with known function in the organization and dynamics of the actin cytoskeleton as well as genes involved in the regulation of apoptosis.
Keywords: (Tet-Off)
Overall design Inducible cell culture system
Contributor(s) Müller T, Concannon C, Ward M, Kögel D, Prehn J, Egensperger R
Citation(s) 17093061
Submission date Jan 25, 2006
Last update date Aug 10, 2018
Contact name Thorsten Mueller
Phone 00491789261547
Fax 00492517477140
Organization name Institute of Neuropathology
Department University Hospital Muenster
Street address Domgakstr. 19
City Muenster
ZIP/Postal code 48149
Country Germany
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (6)
GSM93710 iA50clone6+
GSM93711 iA50clone6-
GSM93712 iA50clone9+
BioProject PRJNA95255

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