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Series GSE40595 Query DataSets for GSE40595
Status Public on Sep 11, 2014
Title A cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of the tumor, understanding in the role of cancer associated fibroblasts (CAFs) in ovarian cancer progression is limited. We hypothesized that comparing the gene expression profiles of different components from laser capture microdissected ovarian tissue will allow us to identify an ovarian CAFs specific gene signature which accounts for the supportive role of CAFs in ovarian cancer progression. In this study, gene expression profiling was completed for 31 cancer stroma samples and 32 samples of epithelial component from high grade serous ovarian cancer patients. 8 microdissected normal ovarian stroma and 6 normal human ovarian surface epithelium (HOSE) samples were also included in the study. By comparing the expression data from cancer stroma against that from normal stroma, cancer cells and HOSE, we identified a set of differential expressed genes in ovarian CAFs which showed correlation with cancer patient survival. Further study on these genes can reveal their roles in ovarian cancer progression and pathogenesis. Ultimately, ovarian CAFs specified genes identified in this study may aid in the classification and enhancement of patient outcome.
 
Overall design Transcriptome profiling analyses were performed on 31 laser microdissected cancer associated stroma samples, 32 epithelial tumor samples from high grade serous ovarian cancer patients, 8 microdissected normal ovarian stroma samples and 6 ovarian surface epthelium (HOSE) samples using the Affymetrix human genome U133 Plus 2.0 microarray.
 
Contributor(s) Birrer MJ, Mok SC, Wong K
Citation(s) 23824740
Submission date Sep 04, 2012
Last update date Mar 25, 2019
Contact name Tsz-Lun Yeung
Organization name University of Texas MD Anderson Cancer Center
Department Gynecologic Oncology and Reproductive Medicine
Street address 1515 Holcombe Blvd. Unit 1362
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (77)
GSM997591 Normal ovarian stroma - sample 5
GSM997592 Normal ovarian stroma - sample 13
GSM997593 Normal ovarian stroma - sample 14
Relations
BioProject PRJNA174358

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE40595_RAW.tar 362.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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