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| Status |
Public on Feb 23, 2014 |
| Title |
Gene expression profiles in wild-type and Jmjd3-/- embryos |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression profiles were compared between wild-type and Jmjd3-/- embryos at E9.5 when mRNAs of posterior Hox genes are upregulated, because Jmjd3-/- mice embryos showed homeotic transformation. As expected, mRNAs of Hoxd10 and Hod11 were decreased in Jmjd3-/- embryos. Moreover, gene onthology (GO) analyses identified down-regulated genes (FC>1.5) in Jmjd3-/- embryos were “multicellular organismal development” and “developmental process”.
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| Overall design |
Gene expressions in wild-type and Jmjd3-/- posterior half of embryos at E9.5 were examined. Two independent RNA samples of each genotypes were used to verify the reproducibility of the microarray analyses.
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| Contributor(s) |
Naruse C, Shibata S, Abe K, Kawaguchi T, Kato T, Nishiuchi T, Asano M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 23, 2012 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Takumi Nishiuchi |
| E-mail(s) |
tnish9@staff.kanazawa-u.ac.jp
|
| Organization name |
Kanazawa University
|
| Street address |
13-1 Takaramachi
|
| City |
Kanazawa |
| ZIP/Postal code |
920-0934 |
| Country |
Japan |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (4)
|
| GSM991395 |
1_RNA from posterior half of Jmjd3-/- embryo |
| GSM991396 |
3_RNA from posterior half of wild-type embryo |
| GSM991397 |
4_RNA from posterior half of wild-type embryo |
| GSM991398 |
9_RNA from posterior half of Jmjd3-/- embryo |
|
| Relations |
| BioProject |
PRJNA173547 |
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