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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 01, 2012 |
| Title |
Induction and molecular signature of pathogenic Th17 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TGF-beta3 produced by developing Th17 cells induces highly pathogenic T cells that are functionally and molecularly distinct from TGF-beta1-induced Th17 cells. The microarray data represent a distinct molecular signature for pathogenic versus non-pathogenic Th17 cells.
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| Overall design |
Total of seven groups with two to four samples per group from two independent experiments. The no cytokines group (Th0) was used as a control to normalize the data.
7 groups:
B6: (IL-1beta, IL-6)
B623: (IL-1beta, IL-6, IL-23)
T16: (TGF-beta1, IL-6)
T1623: (TGF-beta1, IL-6, IL-23)
T36: (TGF-beta3, IL-6)
T3623: (TGF-beta3, IL-6, IL-23)
NOCYTO: no cytokines
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| Contributor(s) |
Lee Y, Awasthi A, Yosef N, Quintana FJ, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Kuchroo VK |
| Citation(s) |
22961052 |
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| Submission date |
Aug 01, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Youjin Lee |
| Organization name |
Harvard Medical School/ Brigham Women's Hospital
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| Street address |
4 Blackfan Circle, HIM#730
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (22)
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| GSM979848 |
T16_60hr, rep2 |
| GSM979849 |
T1623_60hr, rep1 |
| GSM979850 |
T1623_60hr, rep2 |
| GSM979851 |
T36_60hr, rep1 |
| GSM979852 |
T36_60hr, rep2 |
| GSM979853 |
T3623_60hr, rep1 |
| GSM979854 |
T3623_60hr, rep2 |
| GSM979855 |
NOCYTO_60HR, rep1 |
| GSM979856 |
B623_60hr, rep3 |
| GSM979857 |
B6_Il1_60hr, rep1 |
| GSM979858 |
B6_Il1_60hr, rep2 |
| GSM979859 |
NOCYTO_60HR, rep2 |
| GSM979860 |
NOCYTO_g_60HR, rep3 |
| GSM979861 |
NOCYTO_g_60HR, rep4 |
| GSM979862 |
T16_60hr, rep3 |
| GSM979863 |
T16_60hr, rep4 |
| GSM979864 |
T36_60hr, rep3 |
| GSM979865 |
T36_60hr, rep4 |
| GSM979866 |
B623_60hr, rep4 |
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| Relations |
| BioProject |
PRJNA171767 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE39820_RAW.tar |
79.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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