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Series GSE39812 Query DataSets for GSE39812
Status Public on Aug 02, 2012
Title Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway, and the Activation Is Dependent of Monoamine Oxidases
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In this study we show that physiological concentrations of tryptamine (TA) lead to induction of cytochrome P4501A1 transcription through an AhR-dependent mechanism. In addition, we show that activation of the AhR by TA requires a functional monoamino oxidase system, suggesting that TA acts as an AhR proligand possibly by converting to a high-affinity AhR ligand.
Overall design RNA seq was performed from Hepa cells treated with FICZ or TA by SciLifelabs.
Contributor(s) Bergander LV, Cai W, Klocke B, Seifert M, Pongratz I
Citation(s) 22865928
Submission date Aug 01, 2012
Last update date May 15, 2019
Contact name Bernward Klocke
Organization name Genomatix Software GmbH
Street address Bayerstr. 85a
City Munich
ZIP/Postal code D-80335
Country Germany
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (9)
GSM979664 B1 Control rep1
GSM979665 B2 Control rep2
GSM979666 B3 Control rep3
BioProject PRJNA171764
SRA SRP014649

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39812_FB_result_transcript_summary.tsv.txt.gz 8.2 Mb (ftp)(http) TXT
GSE39812_FT_result_transcript_summary.tsv.txt.gz 8.0 Mb (ftp)(http) TXT
GSE39812_F_vs_B_up.txt.gz 2.6 Kb (ftp)(http) TXT
GSE39812_TB_result_transcript_summary.tsv.txt.gz 8.2 Mb (ftp)(http) TXT
GSE39812_T_vs_B_up.txt.gz 872 b (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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