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| Status |
Public on Aug 02, 2012 |
| Title |
Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway, and the Activation Is Dependent of Monoamine Oxidases |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study we show that physiological concentrations of tryptamine (TA) lead to induction of cytochrome P4501A1 transcription through an AhR-dependent mechanism. In addition, we show that activation of the AhR by TA requires a functional monoamino oxidase system, suggesting that TA acts as an AhR proligand possibly by converting to a high-affinity AhR ligand.
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| |
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| Overall design |
RNA seq was performed from Hepa cells treated with FICZ or TA by SciLifelabs.
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| |
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| Contributor(s) |
Bergander LV, Cai W, Klocke B, Seifert M, Pongratz I |
| Citation(s) |
22865928 |
| |
| Submission date |
Aug 01, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Bernward Klocke |
| E-mail(s) |
klocke@genomatix.de
|
| Organization name |
Genomatix Software GmbH
|
| Street address |
Bayerstr. 85a
|
| City |
Munich |
| ZIP/Postal code |
D-80335 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA171764 |
| SRA |
SRP014649 |
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