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| Status |
Public on Apr 15, 2014 |
| Title |
GLOBAL CHANGES IN GENE EXPRESSION OF BARRETT'S ESOPHAGUS COMPARED TO NORMAL SQUAMOUS ESOPHAGUS AND GASTRIC CARDIA TISSUES |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Barrett’s esophagus (BE) is a metaplastic precursor lesion of esophageal adenocarcinoma (EA), the most rapidly increasing cancer in western societies. While the prevalence of BE is increasing, the vast majority of EA occurs in patients with undiagnosed BE. Thus, we sought to identify genes that are altered in BE compared to the normal mucosa of the esophagus, and which may be potential biomarkers for the development or diagnosis of BE.
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| Overall design |
We performed gene expression analysis using HG-U133A Affymetrix chips on fresh frozen tissue samples of Barrett’s metaplasia and matched normal mucosa from squamous esophagus (NE) and gastric cardia (NC) in 43 BE patients.
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| Contributor(s) |
Hyland PL, Hu N, Rotunno M, Su H, Wang C, Wang L, Pfeiffer RM, Gherman B, Giffen C, Dykes C, Dawsey SM, Abnet CC, Johnson KM, Acosta RD, Young PE, Cash BD, Taylor RR |
| Citation(s) |
24714516 |
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| Submission date |
Jul 19, 2012 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Paula Lisa Hyland |
| E-mail(s) |
hylandpl@mail.nih.gov
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| Phone |
301-443-8223
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| Fax |
301-402-4489
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| Organization name |
NCI, NIH
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| Department |
DCEG
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| Lab |
GEB
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| Street address |
6120 Executive Blvd
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| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20895 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (120)
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| Relations |
| BioProject |
PRJNA170991 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE39491_RAW.tar |
184.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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