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Series GSE38711 Query DataSets for GSE38711
Status Public on Aug 10, 2012
Title Mouse ooplasm confers context-specific reprogramming capacity
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and identify specific targets for DNA demethylation as well as NT specific limitations. We find that the ooplasm can confer similar demethylation patterns in both processes except at some repetitive element classes and that germ-line associated promoters are specifically targeted in NT.
Overall design Comparison of DNA methylation patterns in murine fertilization and somatic cell nuclear transfer
Contributor(s) Chan MM, Smith ZD, Egli D, Regev A, Meissner A
Citation(s) 22902786
Submission date Jun 14, 2012
Last update date May 15, 2019
Contact name Michelle M Chan
Organization name UCSF
Lab Weissman Lab
Street address 1700 4th St.
City San Francisco
State/province CA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (9)
GSM948541 TT-BDF1-CAST-1
GSM948542 TT-BDF1-CAST-1a
GSM948543 TT-BDF1-CAST-2
Reanalysis of GSM856495
Reanalysis of GSM856496
Reanalysis of GSM856497
Reanalysis of GSM856498
Reanalysis of GSM856499
Reanalysis of GSM856500
Reanalysis of GSM856505
Reanalysis of GSM856506
Reanalysis of GSM856507
Reanalysis of GSM856512
Reanalysis of GSM856513
Reanalysis of GSM856514
Reanalysis of GSM856515
Reanalysis of GSM856516
Reanalysis of GSM869999
Reanalysis of GSM870000
Reanalysis of GSM870001
Reanalysis of GSM870002
Reanalysis of GSM870003
Reanalysis of GSM870007
Reanalysis of GSM870008
Reanalysis of GSM870009
BioProject PRJNA168490
SRA SRP013748

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38711_RAW.tar 66.3 Mb (http)(custom) TAR (of TXT)
GSE38711_README.txt.gz 795 b (ftp)(http) TXT
GSE38711_mouseNT100bpMe.txt.gz 39.0 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Processed data provided as supplementary file
Processed data are available on Series record
Raw data are available in SRA

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