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| Status |
Public on Jul 12, 2012 |
| Title |
An overlapping protein-coding region in Influenza A Virus Segment 3 modulates the host response |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Segment 3 of influenza A virus contains a second open reading frame accessed via robosomal frameshifting. The frameshift product, PA-Z, comprises the endonuclease domain of viral PA protein with C-terminal demain encoded by the X-ORF and functions to repress cellular gene expression. PA-X also modulates IAV virulence in a mouse infection model.
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| Overall design |
The effect of PA-X deltions were examined using 2 separate mutant influenza viruses (1918-FS/1918-PCT1) and the results compared to wild-type 1918 influenza virus. Balb/c mice were infected and samples harvested at days 3, 5 and 8 days. Four animals/condition were used. Gene expression levels from infected animals were compared to mock animals.
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| Contributor(s) |
Walters K, Jagger BW, Digard P |
| Citation(s) |
22745253 |
| |
| Submission date |
May 22, 2012 |
| Last update date |
Jan 12, 2017 |
| Contact name |
kathie walters |
| E-mail(s) |
kwalters@systemsbiology.org
|
| Organization name |
Institute for Systems Biology
|
| Street address |
401 Terry Ave N
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA167288 |
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