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Series GSE38112 Query DataSets for GSE38112
Status Public on Jul 12, 2012
Title An overlapping protein-coding region in Influenza A Virus Segment 3 modulates the host response
Organism Mus musculus
Experiment type Expression profiling by array
Summary Segment 3 of influenza A virus contains a second open reading frame accessed via robosomal frameshifting. The frameshift product, PA-Z, comprises the endonuclease domain of viral PA protein with C-terminal demain encoded by the X-ORF and functions to repress cellular gene expression. PA-X also modulates IAV virulence in a mouse infection model.
Overall design The effect of PA-X deltions were examined using 2 separate mutant influenza viruses (1918-FS/1918-PCT1) and the results compared to wild-type 1918 influenza virus. Balb/c mice were infected and samples harvested at days 3, 5 and 8 days. Four animals/condition were used. Gene expression levels from infected animals were compared to mock animals.
Contributor(s) Walters K, Jagger BW, Digard P
Citation(s) 22745253
Submission date May 22, 2012
Last update date Jan 12, 2017
Contact name kathie walters
Organization name Institute for Systems Biology
Street address 401 Terry Ave N
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (40)
GSM934775 lung_1918 FS_d3_rep1
GSM934776 lung_1918 FS_d3_rep2
GSM934777 lung_1918 FS_d3_rep3
BioProject PRJNA167288

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38112_RAW.tar 366.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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