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| Status |
Public on Jun 24, 2012 |
| Title |
Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Human and Mice |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of histologically characterized multiple sclerosis (MS) brain lesions in comparison with control brain samples to identify differentially expressed molecules. We identified CD47 as a target of interest and studied its biology in MS and EAE.
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| Overall design |
We isolated total RNA from acute plaque (AP), chronic active plaque (CAP) and chronic plaque (CP) from MS brains and white matter from healthy controls and performed microarray studies.
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| Contributor(s) |
Han MH, Lundgren DH, Jaiswal S, Chao M, Graham K, Axtell RC, Ho PP, Lock CB, Woodward JI, Brownell SE, Zondilova M, Hunt JV, Baranzini SE, Butcher E, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L |
| Citation(s) |
22734047 |
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| Submission date |
May 16, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
May Han |
| E-mail(s) |
mayhan@stanford.edu
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| Phone |
650-721-5737
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| Organization name |
Stanford University
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| Street address |
1201 Welch Road
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| City |
Stanford |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA167092 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38010_RAW.tar |
35.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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