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| Status |
Public on Jun 04, 2013 |
| Title |
In utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood.
Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspring at 2 weeks of age.
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| Overall design |
Pregnant Mice (BALB/c, C57BL/6, C3H/HeARC) mice were exposed to arsenic (or control) via drinking water from day 8 of gestation until the birth of their offspring. After giving birth, mothers were given control drinking water. At 2 weeks post-natal age, total RNA was extracted from peripheral lung tissue of the offspring and analysed on Affymetrix microarrays.
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| Contributor(s) |
Ramsey KA, Bosco A, McKenna KL, Carter KW, Sly PD, Larcombe AN, Zosky GR |
| Citation(s) |
23221970 |
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| Submission date |
May 07, 2012 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Anthony Bosco |
| E-mail(s) |
Anthony.Bosco@telethonkids.org.au
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| Organization name |
Telethon Kids Institute
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| Street address |
100 Roberts Road
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| City |
Subiaco |
| State/province |
WA |
| ZIP/Postal code |
6008 |
| Country |
Australia |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (34)
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| GSM928647 |
Balb/c, Arsenic, female, biological rep1 |
| GSM928648 |
Balb/c, Arsenic, female, biological rep2 |
| GSM928649 |
Balb/c, Arsenic, female, biological rep3 |
| GSM928650 |
Balb/c, Arsenic, male, biological rep1 |
| GSM928651 |
Balb/c, Arsenic, male, biological rep2 |
| GSM928652 |
Balb/c, Arsenic, male, biological rep3 |
| GSM928653 |
Balb/c, Control, female, biological rep1 |
| GSM928654 |
Balb/c, Control, female, biological rep2 |
| GSM928655 |
Balb/c, Control, female, biological rep3 |
| GSM928656 |
Balb/c, Control, male, biological rep1 |
| GSM928657 |
Balb/c, Control, male, biological rep2 |
| GSM928658 |
Balb/c, Control, male, biological rep3 |
| GSM928659 |
C3H/HeARC, Arsenic, female, biological rep1 |
| GSM928660 |
C3H/HeARC, Arsenic, female, biological rep2 |
| GSM928661 |
C3H/HeARC, Arsenic, female, biological rep3 |
| GSM928662 |
C3H/HeARC, Arsenic, male, biological rep1 |
| GSM928663 |
C3H/HeARC, Arsenic, male, biological rep2 |
| GSM928664 |
C3H/HeARC, Arsenic, male, biological rep3 |
| GSM928665 |
C3H/HeARC, Control, female, biological rep1 |
| GSM928666 |
C3H/HeARC, Control, female, biological rep2 |
| GSM928667 |
C3H/HeARC, Control, female, biological rep3 |
| GSM928668 |
C3H/HeARC, Control, male, biological rep1 |
| GSM928669 |
C3H/HeARC, Control, male, biological rep2 |
| GSM928670 |
C3H/HeARC, Control, male, biological rep3 |
| GSM928671 |
C57BL/6, Arsenic, female, biological rep1 |
| GSM928672 |
C57BL/6, Arsenic, female, biological rep2 |
| GSM928673 |
C57BL/6, Arsenic, female, biological rep3 |
| GSM928674 |
C57BL/6, Arsenic, male, biological rep1 |
| GSM928675 |
C57BL/6, Arsenic, male, biological rep2 |
| GSM928676 |
C57BL/6, Arsenic, male, biological rep3 |
| GSM928677 |
C57BL/6, Control, female, biological rep1 |
| GSM928678 |
C57BL/6, Control, female, biological rep3 |
| GSM928679 |
C57BL/6, Control, male, biological rep1 |
| GSM928680 |
C57BL/6, Control, male, biological rep3 |
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| Relations |
| BioProject |
PRJNA163621 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE37831_RAW.tar |
139.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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