|
| Status |
Public on Jan 01, 2013 |
| Title |
Daily cycling of genome-wide histone methylation |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide changes of active and suppressive histone marks control global chromatin architecture over the day and night.
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| |
|
| Overall design |
Examination of mouse liver tissue at 4 time-points around the clock in "free-running", continuous conditions (constant darkness, temperature and food available ad libitum).
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| |
|
| Contributor(s) |
Valekunja UK, Reddy AB |
| Citation(s) |
23297224 |
| |
| Submission date |
Apr 18, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Utham Kashyap Valekunja |
| Organization name |
University of Pennsylvania
|
| Department |
Department of Systems Pharmacology & Therapeutics, Perelman School of Medicine,
|
| Lab |
10-179/180 Smilow Center for Translational Research,
|
| Street address |
3400 Civic Center Boulevard,
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
|
| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE37396 |
The histone methyltransferase MLL3 regulates genome-scale circadian transcription |
|
| Relations |
| SRA |
SRP012311 |
| BioProject |
PRJNA159825 |
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