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Series GSE37035 Query DataSets for GSE37035
Status Public on Apr 01, 2014
Title Polarity gene alterations in pure invasive micropapillary carcinomas of the breast
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary In this study we have identified a new morphological pattern in IMPC defined by the presence of numerous bi-nucleated cells, related to abnormal expression of genes involved in regulation of mitosis. We also demonstrated that IMPC presented tight and adherens junctions proteins expression modifications that could participate to their clinical behavior. We showed that IMPC was associated with a specific genomic profile compared to ER+ grade-matched IDC consisting of gains of 17q, high rates of 17q23 and 17q12 ERBB2 amplifications, losses of heterozygosity of 6q. The putative role of the genes located in this 6q LOH should be further investigated in order to determine if they could play a role in the presence of numerous bi-nucleated cells and inverted polarity of IMPC cells. In addition, we identified two genomic IMPC subsets: the first characterized by numerous amplicons with frequently near-tetraploid cells and the second, associated with different complex gains and losses in addition to 8q gains and 16q losses, and predominantly composed of near-diploïd cells. The observation of two genomic subsets within the IMPC entity suggests the existence of two possible oncogenic mechanisms leading to the development of a single disease.
Overall design Phenotypical analysis was combined with copy number, genotyping (SNP6.0 Affymetrix) and transcriptomic analyses in a series of 39 pure IMPC. The results were compared to those of 27 ER and grade-matched invasive ductal carcinomas (IDC).
Contributor(s) Gruel N, Benhamo V, Popova T, Cedenot A, Mariani O, Gautier A, Cascone I, Arnould L, Fréneaux P, Bhalshankar J, Assayag F, Pierron G, Reyal F, Alran S, Cottu P, Fourquet A, Sastre-Garau X, Stern M, Camonis J, Delattre O, Vincent-Salomon A
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Submission date Apr 04, 2012
Last update date Nov 27, 2018
Contact name Jaydutt D Bhalshankar
Phone 0330156246517
Organization name Institut CURIE
Department INSERM UNIT 830
Lab Genetics and Biology of Cancer
Street address 26 rue d'Ulm
City Paris
ZIP/Postal code 75248
Country France
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (66)
GSM909171 IDC_439455_tumoral sample
GSM909172 IDC_469625_tumoral sample
GSM909173 IDC_488469_tumoral sample
BioProject PRJNA158289

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37035_RAW.tar 2.6 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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