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Series GSE36868 Query DataSets for GSE36868
Status Public on Jul 01, 2012
Title Simvastatin treated Lymphoblastoid Cell lines from Cholesterol and Pharmacogenomics (CAP) Trial
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Statins reduce cardiovascular disease risk by lowering plasma low density lipoprotein (LDL)-cholesterol. To identify novel pathways that modulate statin response, we assessed the influence of simvastatin exposure on expression quantitative trait locus (eQTL) associations across the genome in 480 lymphoblastoid cell lines (LCLs). Cell lines were derived blood samples collected ant entry visit from participants in the Cholesterol and Pharmacogenomics (CAP) trial, who underwent a 6 week 40mg/day simvastatin trial. We identified 4590 cis-eQTLS that were independent of treatment status (FDR=1%) and six cis-eQTLS for which there was evidence of an interaction with treatment (FDR=20%). Genotypes and Phenotypes derived from these indivudals are available through dbGaP (Accession Number). eQTL results are available at: http://eqtl.uchicago.edu/cgi=bin/gbrowse/eqtl/
 
Overall design Dataset consists of 960 expression beadarrays (Illumina HumanRef-8v3) representing paired samples derived from 24-hour exposures of 480 lymphoblastoid cell lines (LCLs) to 2 micromolar simvastatin acid or control buffer.
 
Contributor(s) Mangravite LM, Krauss RM
Citation(s) 24001602, 23935528, 23995691
Submission date Mar 28, 2012
Last update date Sep 11, 2019
Contact name Lara Mangravite
E-mail(s) lara.mangravite@sagebase.org
Organization name Sage Bionetworks
Street address 1100 Fairview Ave North
City Seattle
State/province WA
ZIP/Postal code 98109-1024
Country USA
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (960)
GSM903671 CAP02.0927P
GSM903672 CAP02.0941P
GSM903673 CAP02.0942P
Relations
BioProject PRJNA157039

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36868_CAPexpn_Ave_NBEADS.txt.gz 19.6 Mb (ftp)(http) TXT
GSE36868_CAPexpn_BEAD_STDERR.txt.gz 89.8 Mb (ftp)(http) TXT
GSE36868_CAPexpn_Detection_Pval.txt.gz 31.1 Mb (ftp)(http) TXT
GSE36868_CAPexpn_ave_signal.txt.gz 83.5 Mb (ftp)(http) TXT
GSE36868_RAW.tar 3.9 Mb (http)(custom) TAR
Processed data included within Sample table

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