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| Status |
Public on Oct 31, 2012 |
| Title |
Expression profiling shows differential functions and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Our microarray study validates characteristic functions of serrated adenocarcinoma (SAC) reported in the only previous study which was performed on patients from a dissimilar environmental and genetic background and using a different microarray platform. In our study, fascin1 and hippocalcin were validated at the mRNA and protein level as the best biomarkers reported so far for the distinction of SAC from conventional carcinoma and from colorectal carcinoma showing molecular and histological features of high-level microsatellite instability.
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| Overall design |
In this study, we used gene expression arrays to investigate differences between two experimental classes: serrated and conventional carcinomas
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| Contributor(s) |
Conesa-Zamora P, Garcia-Solano J, Garcia-Garcia F, Turpin M, Trujillo-Santos J, Torres-Moreno D, Oviedo-Ramirez I, Carbonell-Muñoz R, Muñoz-Delgado E, Rodriguez-Braun E, Conesa A, Perez-Guillermo M |
| Citation(s) |
22696308 |
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| Submission date |
Mar 23, 2012 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Francisco García García |
| E-mail(s) |
fgarcia@cipf.es
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| Organization name |
CIPF
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| Department |
Bionformatics & Biostatistics Unit
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| Street address |
Eduardo Primo Yúfera, 3
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| City |
Valencia |
| ZIP/Postal code |
46012 |
| Country |
Spain |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (26)
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| GSM900419 |
CPT, replicate 1, conventional |
| GSM900420 |
CMT, replicate 2, conventional |
| GSM900421 |
CT, replicate 11, conventional |
| GSM900422 |
CT, replicate 5, conventional |
| GSM900423 |
ST, replicate 1, serrated |
| GSM900424 |
SMT, replicate 3, serrated |
| GSM900425 |
CT, replicate 6, conventional |
| GSM900426 |
CT, replicate 7, conventional |
| GSM900427 |
ST, replicate 6, serrated |
| GSM900428 |
SMT, replicate 1, serrated |
| GSM900429 |
CT, replicate 2, conventional |
| GSM900430 |
CT, replicate 3, conventional |
| GSM900431 |
ST, replicate 5, serrated |
| GSM900432 |
CT, replicate 4, conventional |
| GSM900433 |
SMT, replicate 2, serrated |
| GSM900434 |
SMT, replicate 4, serrated |
| GSM900435 |
CT, replicate 8, conventional |
| GSM900436 |
ST, replicate 2, serrated |
| GSM900437 |
CT, replicate 9, conventional |
| GSM900438 |
SPT, replicate 1, serrated |
| GSM900439 |
ST, replicate 3, serrated |
| GSM900440 |
ST, replicate 4, serrated |
| GSM900441 |
CMT, replicate 3, conventional |
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| Relations |
| BioProject |
PRJNA156687 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE36758_RAW.tar |
243.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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