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Series GSE36135 Query DataSets for GSE36135
Status Public on Oct 02, 2012
Title Expression data from prostate cancer Docetaxel-resistant cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Docetaxel is the standard first line therapy for hormone-refractory prostate cancer patients. Here we generated models of Docetaxel resistance in prostate cancer cells to study the molecular pathways that drive the acquisition of resistance to this therapy. We used microarrays to detail the global program of gene expression underlying the acquisition of Docetaxel resistance in prostate cancer cells.
Overall design Parental Docetaxel-sensitive prostate cancer cell lines (DU145 and 22Rv1) and selected Docetaxel-resistant cells (DU145-DR and 22Rv1-DR) were harvested for RNA extraction and hybridization on Affymetrix microarrays. Samples were analyzed in triplicates in order to increase the resolution of expression profiles.
Contributor(s) Domingo-Domenech J, Cordon-Cardo C
Citation(s) 22975379
Submission date Feb 28, 2012
Last update date Mar 25, 2019
Contact name Josep Domingo-Domenech
Phone 212-241-9145
Organization name Mount Sinai School of Medicine
Department Pathology
Street address Annenberg Building, Room 24-16
City New York
State/province New York
ZIP/Postal code 10029
Country USA
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM881715 DU145 parental sensitive 1
GSM881716 DU145 parental sensitive 2
GSM881717 DU145 Docetaxel resistant 1
BioProject PRJNA152947

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36135_RAW.tar 35.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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