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Series GSE34675 Query DataSets for GSE34675
Status Public on Dec 24, 2011
Title Gene Expression from diabetic ischemic limbs in WT and p75KO mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Transcriptome analysis was carried out to characterise the different responses of diabetic and non-diabetic WT and p75KO mice to ischemia
Overall design C57BL/6J-p75NTR-/- (p75KO) and p75NTR+/+ (WT) littermates were bred starting from breeding pairs. Six to seven week old male p75KO and WT mice were made diabetic using streptozotocin (STZ, 40 mg/kg in 0.1mol/l citrate buffer pH4.5 i.p. per day for 5 days or left normoglycemic by STZ buffer injections. One or three months after diabetes induction, anesthetized mice underwent unilateral hindlimb ischemia by permanent ligation and electro-coagulation of the proximal end of femoral arteries. At the same time, full thickness wounds were created in the thigh dorsal skin of both legs using a sterile 5-mm-wide biopsy punch. Samples for gene expression analysis were taken from the wounds three days later.
Contributor(s) Vierlinger K, Emanueli C
Citation(s) 23065828
Submission date Dec 22, 2011
Last update date Jan 12, 2017
Contact name Klemens Vierlinger
Organization name AIT
Department HMD
Street address Giefinggasse 4
City Vienna
ZIP/Postal code 1210
Country Austria
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (12)
GSM853069 MP.12.R5 p75KO.diabetic
GSM853070 MP.6.R1 WT.diabetic
GSM853071 MP.3.R1 WT.healthy
BioProject PRJNA150321

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE34675_RAW.tar 25.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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