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| Status |
Public on Feb 23, 2012 |
| Title |
Whole genome gene expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted comprehensive gene expression profiling in 52 ATL patients and in 21 healthy volunteers.
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| Overall design |
Total RNA samples from PBMC of ATL patients (mostly HTLV-1 inefcted CD4+ T-cells) and from CD4+ T-cells from healthy donors were subjected to Cy-3 labeling followed by human whole genome gene expression microarray analyses.
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| Contributor(s) |
Nakano K, Sato A, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T |
| Citation(s) |
22264793, 26773042, 34376672 |
| |
| Submission date |
Nov 10, 2011 |
| Last update date |
Sep 08, 2021 |
| Contact name |
Kazumi Nakano |
| Organization name |
The University of Tokyo
|
| Department |
Department of Medical Genome Sciences, Graduate School of Frontier Sciences
|
| Lab |
Laboratory of Tumor Cell Biology
|
| Street address |
4-6-1, Sirokanedai, Minatoku
|
| City |
Tokyo |
| ZIP/Postal code |
108-8639 |
| Country |
Japan |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (73)
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| Relations |
| BioProject |
PRJNA148513 |
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