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Series GSE33464 Query DataSets for GSE33464
Status Public on Dec 06, 2011
Title Expression data of multiple sclerosis patients receiving subcutaneous Interferon-beta-1a therapy [U133 Plus 2.0]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1a treatment (Rebif, 22 µg or 44 µg three times a week) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 12 MS patients within the first two years of IFN-beta administration.
 
Overall design EDTA blood samples were taken from all patients immediately before first and second IFN-beta injection as well as after 1 month, 1 year and 2 years. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labeled and hybridized to Affymetrix Human Genome U133 Plus 2.0 arrays to quantify the mRNA levels. This GEO entry provides the U133 Plus 2.0 microarray data.
 
Contributor(s) Hecker M, Koczan D, Goertsches RH, Zettl UK
Citation(s) 22727118, 23636981
Submission date Nov 03, 2011
Last update date May 07, 2013
Contact name Michael Hecker
E-mail(s) michael.hecker@rocketmail.com
Organization name University of Rostock
Department Department of Neurology
Lab Division of Neuroimmunology
Street address Gehlsheimer Str. 20
City Rostock
ZIP/Postal code 18147
Country Germany
 
Platforms (1)
GPL14837 Affymetrix Human Genome U133 Plus 2.0 Array [CDF: XLab gahgu133plus2_2.1.0]
Samples (60)
GSM827806 Patient 1, before first IFN-beta injection
GSM827807 Patient 1, before second IFN-beta injection
GSM827808 Patient 1, 1 month after start of IFN-beta therapy
Relations
BioProject PRJNA148781

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33464_RAW.tar 513.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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