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Series GSE32104 Query DataSets for GSE32104
Status Public on Sep 13, 2012
Title Host gene expression response to Toxoplasma gondii infection is not different between RH∆ku80 and RH∆ku80∆rop5 parasites
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differences between host cells infected with wt (RH∆ku80) or RH∆ku80∆rop5 parasites. We have included uninfected HFF samples that were harvested in parallel with the infected samples.
Overall design Host gene expression in response to infection with Toxoplasma gondii. Two independent samples per sample type. Three sample types: HFF infected with RH∆ku80, HFF infected with RH∆ku80∆rop5, and uninfected HFF.
Contributor(s) Behnke MS, Sibley LD
Citation(s) 23144612
Submission date Sep 13, 2011
Last update date Dec 06, 2018
Contact name Michael Sean Behnke
Organization name Washington University School of Medicine
Department Molecular Microbiology
Lab Dr David Sibley
Street address 660 S. Euclid Ave
City St Louis
State/province MO
ZIP/Postal code 63110
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (6)
GSM796002 HFF + RH-deltaku80 #1
GSM796003 HFF + RH-deltaku80 #2
GSM796004 HFF + RH-deltaku80-deltarop5 #1
BioProject PRJNA147471

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32104_RAW.tar 12.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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