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| Status |
Public on Sep 13, 2012 |
| Title |
Host gene expression response to Toxoplasma gondii infection is not different between RH∆ku80 and RH∆ku80∆rop5 parasites |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differences between host cells infected with wt (RH∆ku80) or RH∆ku80∆rop5 parasites. We have included uninfected HFF samples that were harvested in parallel with the infected samples.
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| |
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| Overall design |
Host gene expression in response to infection with Toxoplasma gondii. Two independent samples per sample type. Three sample types: HFF infected with RH∆ku80, HFF infected with RH∆ku80∆rop5, and uninfected HFF.
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| |
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| Contributor(s) |
Behnke MS, Sibley LD |
| Citation(s) |
23144612 |
| |
| Submission date |
Sep 13, 2011 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Michael Sean Behnke |
| E-mail(s) |
mike_behnke@yahoo.com
|
| Organization name |
Washington University School of Medicine
|
| Department |
Molecular Microbiology
|
| Lab |
Dr David Sibley
|
| Street address |
660 S. Euclid Ave
|
| City |
St Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA147471 |
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