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| Status |
Public on Sep 10, 2011 |
| Title |
Gene expression profiling of colorectal carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify the prognostic gene expression markers in early primary colorectal carcinomas, we analyzed genome-wide gene expression profiles using Agilent 4x44K oligonucleotide microarrays. By SVM we selected a gene signature which discriminated patients which later developed metastasis from patients with a good prognosis. Most of the genes that were found to be informative for patients’ distant recurrence were related to the patient’s immune response. Furthermore, our microarray data confirmed the specificity and sensitivity of the angiogenesis-related genes signature.
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| |
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| Overall design |
Gene expression profiling of 67 specimens of 55 colorectal carcinomas, 7 normal and 5 adenomas was studied.
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| |
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| Contributor(s) |
Wang Q, Fehlker M |
| Citation(s) |
22012870 |
| |
| Submission date |
Sep 06, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Qing Wang |
| E-mail(s) |
wang.qing@mdc-berlin.de
|
| Phone |
+493094063798
|
| Fax |
+493094062846
|
| Organization name |
Charite-Berlin
|
| Department |
Surgical Oncology
|
| Street address |
Robert Rössle Str. 10
|
| City |
Berlin |
| State/province |
Berlin |
| ZIP/Postal code |
13125 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (67)
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|
| Relations |
| BioProject |
PRJNA145219 |
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