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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 01, 2011 |
| Title |
Gene Expression Analysis of Host Innate Immune Responses in the Brain and Spinal cord following Lethal CVS-11 Infection in Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The microarray and advanced pathway analysis of mice caused a paralysis in a fatal infection of a highly pathogenic CVS-11 was performed for the understanding of the detail gene networks and biological functions of inflammatory response and the related genes of innate immunity and apoptosis.
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| Overall design |
Brain Samples: Six female C57BL/6J mice aged six weeks old were inoculated 1E+7 focus-forming units (FFU) of CVS-11 propagated in MNA cells into the left hind limb, intramuscularly. On the other hand, MEM was inoculated into 6 negative control mice in a similar way. Each mice were sacrificed to collect their brains at days 7 postinoculation (dpi). Six mice were used for the analysis of microarray. The six of mock mice were also sacrificed at 7 dpi for the microarray analysis.
Spinalcord Samples: Six female C57BL/6J mice aged six weeks old were inoculated 1E+7 focus-forming units (FFU) of CVS-11 propagated in MNA cells into the left hind limb, intramuscularly. On the other hand, MEM was inoculated into 6 negative control mice in a similar way. Each mice were sacrificed to collect their spinal cords at days 7 postinoculation (dpi). Six mice were used for the analysis of microarray. The six of mock mice were also sacrificed at 7 dpi for the microarray analysis.
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| Contributor(s) |
Sugiura N, Inoue S, Uda A, Kojima D, Kaku Y, Okutani A, Noguti A, Park C, Yamada A |
| Citation(s) |
22116324 |
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| Submission date |
Jul 12, 2011 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Naoko Sugiura |
| E-mail(s) |
nsugiura@nih.go.jp
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| Organization name |
National Institute of Infectious Diseases
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| Street address |
Toyama 1-23-1
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| City |
Shinjuku-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
162-8640 |
| Country |
Japan |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (24)
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| GSM758705 |
Rabies, Fix, Brain, 7dpi(inf), 01 |
| GSM758706 |
Rabies, Fix, Brain, 7dpi(inf), 02 |
| GSM758707 |
Rabies, Fix, Brain, 7dpi(inf), 03 |
| GSM758708 |
Rabies, Fix, Brain, 7dpi(inf), 04 |
| GSM758709 |
Rabies, Fix, Brain, 7dpi(inf), 05 |
| GSM758710 |
Rabies, Fix, Brain, 7dpi(inf), 06 |
| GSM758711 |
Rabies, Fix, Brain, 7dpi(mock), 01 |
| GSM758712 |
Rabies, Fix, Brain, 7dpi(mock), 02 |
| GSM758713 |
Rabies, Fix, Brain, 7dpi(mock), 03 |
| GSM758714 |
Rabies, Fix, Brain, 7dpi(mock), 04 |
| GSM758715 |
Rabies, Fix, Brain, 7dpi(mock), 05 |
| GSM758716 |
Rabies, Fix, Brain, 7dpi(mock), 06 |
| GSM766141 |
Rabies, Fix, Spinalcord, 7dpi(inf), 01 |
| GSM766142 |
Rabies, Fix, Spinalcord, 7dpi(inf), 02 |
| GSM766143 |
Rabies, Fix, Spinalcord, 7dpi(inf), 03 |
| GSM766144 |
Rabies, Fix, Spinalcord, 7dpi(inf), 04 |
| GSM766145 |
Rabies, Fix, Spinalcord, 7dpi(inf), 05 |
| GSM766146 |
Rabies, Fix, Spinalcord, 7dpi(inf), 06 |
| GSM766147 |
Rabies, Fix, Spinalcord, 7dpi(mock), 01 |
| GSM766148 |
Rabies, Fix, Spinalcord, 7dpi(mock), 02 |
| GSM766149 |
Rabies, Fix, Spinalcord, 7dpi(mock), 03 |
| GSM766150 |
Rabies, Fix, Spinalcord, 7dpi(mock), 04 |
| GSM766151 |
Rabies, Fix, Spinalcord, 7dpi(mock), 05 |
| GSM766152 |
Rabies, Fix, Spinalcord, 7dpi(mock), 06 |
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| Relations |
| BioProject |
PRJNA144645 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30577_RAW.tar |
73.2 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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