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| Status |
Public on Aug 03, 2011 |
| Title |
Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Tubuli vs. Control Tubuli) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomeruli and tubuli and was associated with increased glomerulosclerosis even in an additional set of DKD samples.
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| Overall design |
Affymetrix expression arrays were used to identify differentially regulated transcripts in 44 microdissected human kidney samples. Stringent statistical analysis using the Benjamini_Hochberg corrected 2-tailed t-test was used to identify differentially expressed transcripts in control and diseased glomeruli and tubuli.
This Series includes DKD and control tubuli samples.
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| Contributor(s) |
Park AS, Mohtat D, Thomas DB, Woroniecka K, Susztak K |
| Citation(s) |
21752957 |
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| Submission date |
Jul 08, 2011 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Karolina Woroniecka |
| E-mail(s) |
kworonie@gmail.com
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| Organization name |
AECOM
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| Lab |
Susztak
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| Street address |
1300 Morris Park Ave
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| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (22)
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| GSM757017 |
Diabetic Human Kidney 120, Tubuli |
| GSM757018 |
Diabetic Human Kidney 148, Tubuli |
| GSM757019 |
Diabetic Human Kidney 162, Tubuli |
| GSM757020 |
Diabetic Human Kidney 164, Tubuli |
| GSM757021 |
Diabetic Human Kidney 168, Tubuli |
| GSM757022 |
Diabetic Human Kidney 178, Tubuli |
| GSM757023 |
Diabetic Human Kidney 187, Tubuli |
| GSM757024 |
Control Human Kidney 17, Tubuli |
| GSM757025 |
Control Human Kidney 37, Tubuli |
| GSM757026 |
Control Human Kidney 53, Tubuli |
| GSM757027 |
Control Human Kidney 64, Tubuli |
| GSM757028 |
Control Human Kidney 70, Tubuli |
| GSM757029 |
Control Human Kidney 76, Tubuli |
| GSM757030 |
Control Human Kidney 77, Tubuli |
| GSM757031 |
Control Human Kidney 81, Tubuli |
| GSM757032 |
Control Human Kidney 82, Tubuli |
| GSM757033 |
Control Human Kidney 160, Tubuli |
| GSM757034 |
Control Human Kidney 172, Tubuli |
| GSM757035 |
Control Human Kidney 177, Tubuli |
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| This SubSeries is part of SuperSeries: |
| GSE30122 |
Transcriptome Analysis of Human Diabetic Kidney Disease |
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| Relations |
| BioProject |
PRJNA154759 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30529_RAW.tar |
45.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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