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Series GSE30052 Query DataSets for GSE30052
Status Public on Apr 17, 2012
Title Dynamics of two oscillation phenotypes in S. cerevisiae [4hr]
Platform organisms Schizosaccharomyces pombe; Saccharomyces cerevisiae
Sample organism Saccharomyces cerevisiae
Experiment type Expression profiling by array
Summary Genetic and environmental factors influence the phenotype of an organism. Time is rarely considered when studying changes in cellular phenotype. Time-resolved microarray data revealed genome-wide transcriptional changes in cells oscillating with ~2 and ~4 h periods. We mapped the global patterns of transcriptional oscillations into a 3-dimensional map to represent different cellular phenotypes of oscillation period. This map shows the dynamic nature of transcripts through time and concentration space, and that they are ordered and coupled to each other. Although cells differed in oscillation periods, transcripts involved in certain processes were conserved in a deterministic way. This ordered timing of biological process may allow cells to grow energetically efficient. Decreased glucose levels in the media were found to increase the redox cycles of yeast strain CEN.PK113-7D. Glucose may have acted as signaling molecules for timing longer catabolic processes in the cell population. As oscillation period lengthened, the peak to trough ratio of transcripts increased and the percent of cells in the unbudded (G0/G1) phase of the cell cycle increased. Gene transcripts appear to be coordinated with metabolic functions and the cell cycle.
 
Overall design High-resolution samples over time were collected for CEN.PK113-7D oscillating with 4 hour period.
 
Contributor(s) Chin SL, Marcus I, Klevecz RR, Li CM
Citation(s) 22289124
Submission date Jun 17, 2011
Last update date Feb 21, 2017
Contact name shwe lynn chin
E-mail(s) shwe2414@yahoo.com
Organization name Beckman Research Institute
Department Biology
Street address 1500 E Duarte Rd.
City Duarte
ZIP/Postal code 91010
Country USA
 
Platforms (1)
GPL2529 [Yeast_2] Affymetrix Yeast Genome 2.0 Array
Samples (49)
GSM743977 CEN.PK113-7D, 4h oscillation period 14 h
GSM743978 CEN.PK113-7D, 4h oscillation period 14.083333 h
GSM743979 CEN.PK113-7D, 4h oscillation period 14.166667 h
This SubSeries is part of SuperSeries:
GSE30053 Dynamics of two oscillation phenotypes in S. cerevisiae reveal a network of genome-wide transcriptional and cell cycle oscillators.
Relations
BioProject PRJNA155161

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30052_RAW.tar 53.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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