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Series GSE29733 Query DataSets for GSE29733
Status Public on Aug 02, 2012
Title Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary These tissue were harvested to complement and extend the studies that generated GSE23093. They served 3 purposes; 1) identify genes important to choroid plexus function and compare them with those important for meninges and associated vasculature (MAV) function, 2) determine genes in the choroid plexus and sensitivity hyperthermia and amphetamine toxicity, 3) identify the important gene expression changes related to the immune system in MAV, choroid plexus and trunk' blood
 
Overall design Gene mRNA expression patterns in choroid plexus and trunk blood were determined under control conditions as well as after (3 hr and 1day) exposure to either environmentally-induced hyperthermia or neurotoxic doses of amphetamine. This data was analyzed and compared to data from meninges and associated vasculature previously deposited in GEO. The data gathered under control conditions was used to further understand how the choroid plexus and meninges and associated vasculature might function to generate and regulate the cerebrospinal fluid. The expression patterns in the choroid plexus after environmentally-induced hyperthermia or neurotoxic doses of amphetamine was determine its damage and protective responses. The expression patterns after environmentally-induced hyperthermia or neurotoxic doses of amphetamine were compared among choroid plexus, meninges and associated vasculature and blood were analyzed to determine immune system responses.
 
Contributor(s) Bowyer JF, Saini UT, Patterson TA, George NI, Chen JJ, Thomas M
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Submission date Jun 03, 2011
Last update date Sep 13, 2014
Contact name John Francis Bowyer
E-mail(s) john.bowyer@fda.hhs.gov
Phone 870-543-7194
Organization name National Center for Toxicological Research FDA
Department Neurotoxicology
Lab Neurobiology
Street address 3900 NCTR Drive
City Jefferson
State/province AR
ZIP/Postal code 72079-9502
Country USA
 
Platforms (1)
GPL7294 Agilent-014879 Whole Rat Genome Microarray 4x44K G4131F (Probe Name version)
Samples (44)
GSM737162 Choroid plexus 3 hr Control Rats MT1, MT2 & MT31
GSM737163 Choroid plexus 3 hr Control Rats MT63, MT64 & MT65
GSM737164 Choroid plexus 3 hr Control Rats MT3, MT4 & MT33
Relations
BioProject PRJNA141153

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29733_RAW.tar 182.2 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table
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