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| Status |
Public on May 24, 2011 |
| Title |
Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify the gene signature accounting for the distinct clinical outcomes in ovarian clear cell cancer patients
Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. Arrays analyzed using BRB ArrayTools and PathwayStudio software was used to identify the signaling pathways.
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| Overall design |
Gene expression profiling was completed for 10 clear cell ovarian cancer specimens and 10 normal ovarian surface epithelium using the Affymetrix human U133 Plus 2.0 Arrays
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| |
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| Contributor(s) |
Birrer MJ |
| Citation(s) |
21754983 |
| |
| Submission date |
May 23, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Michael Birrer |
| E-mail(s) |
mbirrer@partners.org
|
| Phone |
6177244800
|
| Organization name |
MGH
|
| Department |
Medicine
|
| Lab |
Surgical Oncology Research Labs
|
| Street address |
70 Blossom Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (20)
|
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| Relations |
| BioProject |
PRJNA141567 |
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