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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 31, 2012 |
| Title |
Ares Swanson MBNL mutant study |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
MBNL1 is a known splicing factor and is related to Myotonic Dystrophy (DM).
This study examines the tissue specific splicing patterns of MBNL1 using a
mutant and wild type mouse across three tissues (heart,brain,quadricep)
related publications:
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.
Du H, etal
Nat Struct Mol Biol. 2010 Feb;17(2):187-93.
and
Muscleblind-like 1 knockout mice reveal novel splicing defects in the myotonic dystrophy brain.
Suenaga K, Lee KY, Nakamori M, Tatsumi Y, Takahashi MP, Fujimura H, Jinnai K, Yoshikawa H, Du H, Ares M Jr, Swanson MS, Kimura T.
PLoS One. 2012;7(3):e33218. Epub 2012 Mar 13.
PMID: 22427994
and
Hum Mol Genet. 2006 Jul 1;15(13):2087-97.
Failure of MBNL1-dependent post-natal splicing transitions in myotonic
dystrophy.
Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA.
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| Overall design |
We examined quadricep,heart and brain of a mouse MBNL1 mutant
to test whether MBNL mutants creates a tissue specific splicing defect.
These samples were compared to the tissues of a wild type mouse.
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| Contributor(s) |
Du H, Ares M, Swanson M |
| Citation(s) |
20098426, 22427994 |
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| Submission date |
Apr 14, 2011 |
| Last update date |
Nov 08, 2012 |
| Contact name |
Manny Ares |
| Organization name |
UCSC
|
| Department |
Molecular and Cellular Biology
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| Lab |
Ares
|
| Street address |
1125 High St
|
| City |
Santa Cruz |
| State/province |
CA |
| ZIP/Postal code |
95062 |
| Country |
USA |
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| Platforms (1) |
| GPL2720 |
ares_ucsc_mouse_59198_affyMouseA |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA138891 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28640_RAW.tar |
55.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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