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| Status |
Public on Jul 01, 2013 |
| Title |
Effects of 20 months Dietary Methionine Restriction on Gene Expression in inguinal white adipose tissue of Fischer 344 Rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the inguinal white adipose tissue (IWAT).
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| Overall design |
We analyzed MR-induced changes in gene expression using pooled RNA from IWAT of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.
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| Contributor(s) |
Boudreau A, Plaisance EP, Hasek BE, Lenard NR, Stewart LK, Henagan TM, Gettys TW |
| Citation(s) |
23801581 |
| Submission date |
Apr 13, 2011 |
| Last update date |
Jul 01, 2013 |
| Contact name |
Kirsten P Stone |
| E-mail(s) |
kirsten.stone@pbrc.edu
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| Organization name |
Pennington Biomedical Research Center
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| Street address |
6400 Perkins Rd
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| City |
Baton Rouge |
| ZIP/Postal code |
70808 |
| Country |
USA |
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| Platforms (1) |
| GPL2996 |
ABI Rat Genome Survey Microarray |
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| Samples (8)
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| GSM707762 |
Control IWAT Gettys06_CON_IWAT4 |
| GSM707763 |
Methionine restriction Gettys06_MR_IWAT1 |
| GSM707764 |
Methionine restriction Gettys06_MR_IWAT2 |
| GSM707765 |
Methionine restriction Gettys06_MR_IWAT3 |
| GSM707766 |
Methionine restriction Gettys06_MR_IWAT4 |
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| Relations |
| BioProject |
PRJNA139099 |
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