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| Status |
Public on Sep 01, 2011 |
| Title |
Expression pattern of Pseudomonas aeruginosa biofilm-residing bacteria exposed to gentamicin or surface acoustic waves or gentamicin and surface acoustic waves combined |
| Platform organism |
Pseudomonas aeruginosa |
| Sample organism |
Pseudomonas aeruginosa PAO1 |
| Experiment type |
Expression profiling by array
|
| Summary |
Bacteria are known to respond to various environmental stimuli including nutrient deprivation, osmotic stress, and exposure to antibiotics. Our experimental data showed that P. aeruginosa biofilm formed in urinary catheters is very suseptible to gentamicin treatment when combined with exposure to surface acoustic waves
Our goal was to establish whether P. aeruginosa is capable of specifically sensing the surface acoustic waves as well as to try and decipher the molecular mechanism underlying the increased biofilm suseptibility to antibiotics treatment
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| Overall design |
To fully assess the bacterial response we subjected the P. aeruginosa biofilm to four different treatments: control (no treatment); gentamicin treatment alone; surface acoustic waves treatment alone and combined treatment of gentamicin with surface acoustic waves.
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| Contributor(s) |
Kopel M, Banin E |
| Citation missing |
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| |
| Submission date |
Mar 22, 2011 |
| Last update date |
Jul 06, 2016 |
| Contact name |
Ehud Banin |
| E-mail(s) |
banine@mail.biu.ac.il
|
| Organization name |
Bar-Ilan University
|
| Street address |
Bldg 206
|
| City |
Ramat-Gan |
| ZIP/Postal code |
52900 |
| Country |
Israel |
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| Platforms (1) |
| GPL84 |
[Pae_G1a] Affymetrix Pseudomonas aeruginosa Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA139731 |
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