|
| Status |
Public on Sep 30, 2024 |
| Title |
Human Immune Exhaustion Gene Expression Profile in C7R-CAR and CAR NK cells |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
The purpose of this experiment was two-fold. The first was to examine how the gene expression profile changes over time in C7R-CAR NK cells. C7R is a constitutively active IL-7 receptor that provides persistent activation of STAT5. The second was to examine the differential gene expression in C7R CAR NK cells or CAR NK treated with exogenous IL-15 (exIL15) after 2 weeks of stimulation.
|
| |
|
| Overall design |
There are 9 experimental samples. Total RNA from C7R-GD2.CAR NK cells is represented at two different timepoints, the day 0 timepoint an day 14 timepoint. Each condition is represented by 3 matched donors. Total RNA was isolated at 14 from GD2.CAR NK cells treated with exogenous IL-15 to enable two week comparison of C7R and IL-15 signaling.
|
| |
|
| Contributor(s) |
Dysthe M, Parihar R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 18, 2024 |
| Last update date |
Sep 30, 2024 |
| Contact name |
Matthew Dysthe |
| E-mail(s) |
Matthew.Dysthe@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL33412 |
Nanostring nCounter Immune Exhaustion Panel [NS_Hs_Exhaustion_v1.0] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA1162526 |
Less...
More...