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| Status |
Public on Sep 16, 2024 |
| Title |
Retinoic acid and TGF-β orchestrate organ-specific programs of tissue-residency |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Tissue-resident memory T (TRM) cells are integral to tissue immunity, persisting in diverse anatomical sites where they adhere to a common transcriptional framework. How these cells integrate distinct local cues to adopt the common TRM cell fate remains poorly understood. Here, we show that while skin TRM cells strictly require TGF-β for tissue residency, those in other locations utilize the metabolite retinoic acid (RA) to drive an alternative differentiation pathway, directing a TGF-β-independent tissue residency program in the liver and synergizing with TGF-β to drive the TRM cells in the small intestine.
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| Overall design |
OT-I WT and OT-I Tbx21-/- cells were co-transferred into LCMV-OVA infected mice and isolated from the SI for ATAC sequencing 8 days post LCMV-OVA infection.
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| Contributor(s) |
Buquicchio FA, Lareau CA, Obers A, Satpathy AT, Evrard M, Mackay LK |
| Citation missing |
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| |
| Submission date |
Sep 13, 2024 |
| Last update date |
Sep 17, 2024 |
| Contact name |
Caleb Lareau |
| E-mail(s) |
lareauc@mskcc.org
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| Organization name |
Memorial Sloan Kettering
|
| Street address |
417 E 68th St, Zuckerman - ZRC 1132
|
| City |
New York |
| State/province |
New York |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1160824 |
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