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| Status |
Public on May 29, 2012 |
| Title |
Highly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a primary role of this cell type for the cytokine storm.
Our data point to a viral strategy of HPAIV to bypass a major amplifier of the initial local inflammatory response thereby hampering antiviral effector mechanisms and facilitating virus spreading and systemic disease.
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| Overall design |
Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1)
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| Contributor(s) |
Friesenhagen J, Roth J, Börgeling Y, Hrincius E, Ludwig S, Viemann D |
| Citation(s) |
22442495 |
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| Submission date |
Mar 07, 2011 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Dorothee Viemann |
| E-mail(s) |
Viemann.Dorothee@mh-hannover.de
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| Phone |
+49-511-532 - 7823
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| Organization name |
Hannover Medical School
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| Department |
Department of Pediatric Pulmonology, Allergy and Neonatology
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| Street address |
Carl-Neuberg-Straße 1
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| City |
Hannover |
| State/province |
Deutschland |
| ZIP/Postal code |
30625 |
| Country |
Germany |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (12)
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| GSM686089 |
control macrophages, biological rep1 |
| GSM686090 |
control macrophages, biological rep2 |
| GSM686091 |
control macrophages, biological rep3 |
| GSM686092 |
PR8-infected macrophages, biological rep1 |
| GSM686093 |
PR8-infected macrophages, biological rep2 |
| GSM686094 |
PR8-infected macrophages, biological rep3 |
| GSM686095 |
FPV-infected macrophages, biological rep1 |
| GSM686096 |
FPV-infected macrophages, biological rep2 |
| GSM686097 |
FPV-infected macrophages, biological rep3 |
| GSM686098 |
H5N1-infected macrophages, biological rep1 |
| GSM686099 |
H5N1-infected macrophages, biological rep2 |
| GSM686100 |
H5N1-infected macrophages, biological rep3 |
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| Relations |
| BioProject |
PRJNA138131 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE27702_RAW.tar |
25.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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