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Series GSE276576 Query DataSets for GSE276576
Status Public on Oct 01, 2024
Title Genomic reconstruction of Galápagos dog history reveals strategies for management of an invasive species
Organism Canis lupus familiaris
Experiment type SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary Free-breeding dogs have occupied the Galápagos islands at least since the 1830s, however, it was not until the 1900s that dog populations grew substantially, endangering wildlife and spreading disease. In 1981, authorities sanctioned the culling of free-roaming dogs. Yet there are currently large free-roaming dog populations of unknown ancestry on the islands of Isabela and Santa Cruz, whose ancestry has never been assessed on a genome-wide scale. Thus, we performed a complete genomic analysis of the current Galápagos dog population as well as historical Galápagos dogs sampled between 1969 and 2003, testing for population structure, admixture, and shared ancestry. Our dataset included samples from 187 modern and six historical Galápagos dogs, together with whole genome sequence from over 2,000 modern purebred and village dogs. Our results indicate that modern Galápagos dogs are recently admixed with purebred dogs but show no evidence of a population bottleneck related to the culling. Additionally, IBD analyses reveal evidence of shared shepherd-dog ancestry in the historical Galápagos dogs. Overall, our results demonstrate that the 1980s culling of dogs was ineffective in controlling population size and did little to reduce genetic diversity, instead producing a stable and expanding population with genomic signatures of historical dogs remaining today. The insights from this study can be used to improve population control strategies for the Galápagos Islands and other endangered endemic communities worldwide.
 
Overall design 187 samples of free-roaming dogs collected from Santa Cruz and Isabela Islands in the Galápagos
 
Contributor(s) Spatola GJ, Feuerborn TR, Betz JB, Buckley RM, Ostrander GK, Dutrow EV, Velez A, Pinto M, Hale JM, Barnett BD, Mousseau TA, Ostrander EA
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Submission date Sep 06, 2024
Last update date Oct 01, 2024
Contact name Alexander Christian Harris
E-mail(s) alex.harris@nih.gov
Phone 301-402-2016
Organization name National Institutes of Health
Department National Human Genome Research Institute
Lab Ostrander
Street address 50 South Drive
City Bethesda
State/province Maryland
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL17481 Illumina CanineHD BeadChip
Samples (187)
GSM8502295 MUTT, 38313
GSM8502296 MUTT, 38314
GSM8502297 MUTT, 38315
Relations
BioProject PRJNA1157868

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE276576_GEO_202409_Spatola_DetailedGenotypes.txt.gz 197.7 Mb (ftp)(http) TXT
GSE276576_GEO_202409_Spatola_MatrixIntensities.txt.gz 409.6 Mb (ftp)(http) TXT
GSE276576_GEO_202409_Spatola_MatrixProcessed.txt.gz 483.3 Mb (ftp)(http) TXT
GSE276576_RAW.tar 500.7 Mb (http)(custom) TAR (of IDAT)

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