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Series GSE27522 Query DataSets for GSE27522
Status Public on Mar 15, 2011
Title Gene expression in Tcf4Het ApcHet mouse colon tumors compared to normal colon
Organism Mus musculus
Experiment type Expression profiling by array
Summary The Wnt/β-catenin pathway plays multiple/diverse roles in development by regulating gene expression via Tcf/Lef DNA binding factors. Misregulation of this pathway is thought to initiate colon adenoma formation. It is controversial whether Tcf4 (Tcf7L2) functions as an oncogene or tumor suppressor gene in colon carcinogenesis. We show here that Tcf4 haploinsufficiency results in colon tumor formation in a mouse tumor model that normally only develops small intestinal tumors. Further, we show that loss of Tcf4 early in development and in adult colon results in increased cell proliferation. These findings strongly suggest that Tcf4 normally modulates proliferation of the colonic epithelium and that disruption of Tcf4 activity increases proliferation leading to colon tumorigenesis. Taken together our in vivo studies favor a tumor suppressor function for Tcf4.
Overall design 4 Normal Colon and 4 colon tumor from independent mouse tissue samples
Contributor(s) Capecchi MR, Angus-Hill ML
Citation(s) 21383188
Submission date Feb 25, 2011
Last update date Jan 12, 2017
Contact name Mario R. Capecchi
Organization name University of Utah
Street address 15 North 2030 East
City Salt Lake City
State/province UT
ZIP/Postal code 84112
Country USA
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (8)
GSM679827 Colon_Tumor_Adult_1
GSM679828 Colon_Normal_Adult_1
GSM679829 Colon_Normal_Adult_2
BioProject PRJNA137107

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27522_RAW.tar 64.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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