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| Status |
Public on Aug 17, 2024 |
| Title |
Chronic Stress Reinforces the BLA-mPFC-LHb Neural Circuit Leading to Depression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To explore the specific subset of mPFC neurons involved in the pathophysiological process of CRS-induced depression, we performed RNAseq between noCRS and CRS treatment mice to identify the enriched genes and possible pathway. GO:BP analysis identified significantly enriched genes that are involved in synaptic signaling and regulation of membrane potential pathways.
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| Overall design |
Differential expression analysis and GO Enrichment Analysis of RNA seq data. We performed differential expression analysis of RNA seq data obtained from mPFC-LHB projection neurons of noCRS and CRS mice.
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| Contributor(s) |
Qin R, Liu Z, Wen X, Sun W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 10, 2024 |
| Last update date |
Aug 17, 2024 |
| Contact name |
Zhiyuan Liu |
| E-mail(s) |
liuzy0726@gmail.com
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| Organization name |
Chinese Institute for Brain Research, Beijing(CIBR)
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| Street address |
YIKE Road
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| City |
Beijing |
| ZIP/Postal code |
102206 |
| Country |
China |
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| Platforms (1) |
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| Samples (7)
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| GSM8450037 |
RNA-seq, mouse brain mPFC-LHB projection neurons, noCRS-1 |
| GSM8450038 |
RNA-seq, mouse brain mPFC-LHB projection neurons, noCRS-2 |
| GSM8450039 |
RNA-seq, mouse brain mPFC-LHB projection neurons, noCRS-3 |
| GSM8450040 |
RNA-seq, mouse brain mPFC-LHB projection neurons, CRS-1 |
| GSM8450041 |
RNA-seq, mouse brain mPFC-LHB projection neurons, CRS-2 |
| GSM8450042 |
RNA-seq, mouse brain mPFC-LHB projection neurons, CRS-3 |
| GSM8450043 |
RNA-seq, mouse brain mPFC-LHB projection neurons, CRS-4 |
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| Relations |
| BioProject |
PRJNA1146723 |
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