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| Status |
Public on Aug 26, 2024 |
| Title |
Transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor development in MTB-TAN mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We have previously shown that transgenic overexpression of the miR-200b/200a/429 cluster prevents mammary tumor development in MTB-IGFIR mice. In this study we evaluated whether the miR-200b/200a/429 cluster could also prevent mammary tumor development from a different oncogene, namely Neu/Erbb2. We found that transgenic overexpression of Neu/Erbb2 in MTB-TAN mice induce rapid mammary tumor development and co-overexpression of the miR-200b/200a/429 cluster with Neu/Erbb2 completely prevent mammary epithelial transformation and tumor development
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| Overall design |
RNA was extracted from mammary gland from 55 day old control, MTB-TAN (overexpress Neu), and MTB-TANba429 (overexpress both Neu and miR-200b/200a/429 cluster) mice as well as mammary tumors from MTB-TAN mice
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| Contributor(s) |
Moorehead R |
| Citation missing |
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| |
| Submission date |
Jun 27, 2024 |
| Last update date |
Aug 26, 2024 |
| Contact name |
Roger Moorehead |
| E-mail(s) |
rmoorehe@uoguelph.ca
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| Organization name |
University of Guelph
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| Department |
Biomedical Sciences
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| Street address |
50 Stone Rd E
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| City |
Guelph |
| ZIP/Postal code |
N1G2W1 |
| Country |
Canada |
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| Platforms (1) |
| GPL34290 |
Illumina NovaSeq X Plus (Mus musculus) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA1129144 |
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